low price 1628260-79-6 On Sale GLPG1690 ziritaxestat exporter CAS NO.1628260-79-6

low price 1628260-79-6 On Sale GLPG1690 ziritaxestat exporter

GLP1690 is a potent inhibitor of autotaxin (K_i = 15 nM).It inhibits the production of lysophosphatidic acid (LPA) in mouse, rat, and human plasma (IC₅₀s = 418, 542, and 242 nM, respectively). GLPG1690 (30 mg/kg) reduces extracellular matrix deposition in the lung as well as LPA 18:2 levels in bronchoalveolar lavage fluid in a mouse model of pulmonary fibrosis induced by bleomycin 

Ziritaxestat, also known as GLPG1690, is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement.

GLPG1690 is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement. 

GLPG1690 is one of numerous organic compounds composing American Elements's comprehensive catalog of life science products. American Elements supplies life science materials in most volumes including bulk quantities and also can produce materials to customer specifications. Most materials can be produced in high and ultra high purity forms (99%, 99.9%, 99.99%, 99.999%, and higher) and to many standard grades when applicable including Mil Spec (military grade), ACS, Reagent and Technical Grades, Pharmaceutical Grades, Optical, Semiconductor, and Electronics Grades. Please request a quote above for more information on pricing and lead time.