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1876467-74-1 BAY-1895344 HCl best quality 1876467-74-1 Wholesaler 1876467-74-1 CAS NO.1876467-74-1
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- Min.Order: 1 Gram
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- Available Specifications:
99%(1-5)Gram98%(1-5)Gram
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Quick Details
- ProName: 1876467-74-1 BAY-1895344 HCl best qual...
- CasNo: 1876467-74-1
- Molecular Formula: C20H22ClN7O
- Appearance: Powder
- Application: Scientific research
- DeliveryTime: Prompt
- PackAge: As required
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: keep sealed and keep from direct light
- Transportation: By Sea/Air/FedEx
- LimitNum: 1 Gram
- Moisture Content: N/A
- Impurity: N/A
- Grade: Industrial Grade，Pharma Grade
Superiority
1876467-74-1 BAY-1895344 HCl best quality 1876467-74-1 Wholesaler
Elimusertib, also known as BAY-1895344, is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.
BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR; IC50 = 0.007 µM). It is selective for ATR over DNA protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), and PI3Kβ (IC50s = 0.332, 1.42, and 3.27 µM, respectively). BAY-1895344 inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells with IC50 values of 0.16, 0.071, and 0.009 µM, respectively. It reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 mouse xenograft model when administered at a dose of 50 mg/kg. BAY-1895344 is synergistic with carboplatin, olaparib, or radiation in various mouse xenograft models.
Details
| Catalogue Number | B118925 |
| Chemical Name | BAY-1895344 |
| Synonyms | (R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine |
| CAS Number | 1876467-74-1 |
| Molecular Formula | C??H??N?O |
| Appearance | Orange Solid |
| Melting Point | >200°C (dec.) |
| Molecular Weight | 375.43 |
| Storage | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor used in the treatment of advanced hyperproliferative disease, prophylaxis, solid tumors and lymphomas. |