China (Mainland)
High Purity 1415823-73-2 1415823-73-2 in bulk supply evobrutinib in stock CAS NO.1415823-73-2
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- Min.Order: 1 Gram
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- Available Specifications:
99%(1-5)Gram98%(1-5)Gram
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Keywords
- High Purity 1415823-73-2
- 1415823-73-2 in bulk supply
- evobrutinib in stock
Quick Details
- ProName: High Purity 1415823-73-2 1415823-73-2 ...
- CasNo: 1415823-73-2
- Molecular Formula: C25H27N5O2
- Appearance: Powder
- Application: Scientific research
- DeliveryTime: Prompt
- PackAge: As required
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: keep sealed and keep from direct light
- Transportation: By Sea/Air/FedEx
- LimitNum: 1 Gram
- Moisture Content: N/A
- Impurity: N/A
- Grade: Industrial Grade，Pharma Grade
Superiority
High Purity 1415823-73-2 in bulk supply evobrutinib in stock
Evobrutinib is an inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 8.9 nM).It is selective for BTK over a panel of 233 kinases at 1 μM. It inhibits BTK in peripheral blood mononuclear cells (PBMCs; IC50 = 61 nM). Evobrutinib inhibits B cell activation and proliferation in vitro (IC50s = 18.4 and 10.9 nM, respectively). It inhibits mast cell degranulation in a mouse model of passive cutaneous anaphylaxis when administered at doses of 3.95, 19.8, and 39.5 mg/kg. Evobrutinib (1 and 3 mg/kg) reduces cartilage destruction in a rat model of collagen-induced arthritis. It also decreases proteinuria, interstitial inflammation, and the number of glomerular lesions and preserves kidney function in a mouse model of systemic lupus erythematosus (SLE).
Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174.
Evobrutinib can inhibit the activity of BTK and prevent the activation of the BCR signaling pathway. It is metabolized via hydroxylation, hydrolysis, O-dealkylation, glucuronidation, and GSH conjugation.
Details
| Catalogue Number | E947503 |
| Chemical Name | Evobrutinib |
| Synonyms | 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one; M-2951;MSC-2364447C |
| CAS Number | 1415823-73-2 |
| Molecular Formula | C??H??N?O? |
| Appearance | White to Off-White Solid |
| Melting Point | 173 - 174ºC |
| Molecular Weight | 429.51 |
| Storage | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Stability | Hygroscopic |
| Category | Standards; Enzyme Activators and Inhibitors; |
| Applications | Evobrutinib is a highly selective inhibitor of the Bruton’s tyrosine kinase (BTK), which is important in the development and functioning of various immune cells including B lymphocytes and macrophages. Preclinical research suggests it may be therapeutically useful in certain autoimmune diseases. |