Fast Delivery 909910-43-6 Manufacturer Hot Sale A-83-01 CAS NO.909910-43-6
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- Min.Order: 1 Gram
- Payment Terms: T/T,Other
- Available Specifications:
99%(1-5)Gram98%(1-5)Gram
- Product Details
Keywords
- Fast Delivery 909910-43-6
- 909910-43-6 Manufacturer
- Hot Sale A-83-01
Quick Details
- ProName: Fast Delivery 909910-43-6 Manufacturer...
- CasNo: 909910-43-6
- Molecular Formula: C25H19N5S
- Appearance: Powder
- Application: Scientific research
- DeliveryTime: Prompt
- PackAge: As required
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: keep sealed and keep from direct light
- Transportation: By Sea/Air/FedEx
- LimitNum: 1 Gram
- Grade: Industrial Grade,Pharma Grade
Superiority
Fast Delivery 909910-43-6 Manufacturer Hot Sale A-83-01
A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK. A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 lonly weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. A 83-01 is more potent than SB 431542. Fibroblasts can be reprogrammed by A 83-01 into alternative lineages.
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.
Details
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Product name
A 83-01, ALK4, 5 and 7 kinase inhibitor
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Description
Potent ALK4, 5 and 7 kinase inhibitor
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Alternative names
- A-83-01
- A83-01
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Purity
> 98%
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CAS Number
909910-43-6
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Chemical structure