China (Mainland)
1204144-28-4 Good Supplier In China 1204144-28-4 on hot selling Pharmaceutical grade AZD-1208 CAS NO.1204144-28-4
- FOB Price: USD: /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: T/T,Other
- Available Specifications:
99%(1-5)Gram98%(1-5)Gram
- Product Details
Keywords
- 1204144-28-4 Good Supplier In China
- 1204144-28-4 on hot selling
- Pharmaceutical grade AZD-1208
Quick Details
- ProName: 1204144-28-4 Good Supplier In China 12...
- CasNo: 1204144-28-4
- Molecular Formula: C21H21N3O2S
- Appearance: Powder
- Application: Scientific research
- DeliveryTime: Prompt
- PackAge: As required
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: keep sealed and keep from direct light
- Transportation: By Sea/Air/FedEx
- LimitNum: 1 Gram
- Moisture Content: N/A
- Impurity: N/A
- Grade: Industrial Grade，Pharma Grade
Superiority
1204144-28-4 Good Supplier In China 1204144-28-4 on hot selling Pharmaceutical grade AZD-1208
AZD 1208 is a potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. Chemosensitizer.
AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively). It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice. It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110α inhibitors, respectively.
Details
| Alternate Name | 5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione |
|---|---|
| Appearance | Pale yellow solid |
| CAS # | 1204144-28-4 |
| Molecular Formula | C??H??N?O?S |
| Molecular Weight | 379.48 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | C1CC(CN(C1)C2=C(C=CC=C2C=C3C(=O)NC(=O)S3)C4=CC=CC=C4)N |
| InChi | InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1 |
| InChi Key | MCUJKPPARUPFJM-UWCCDQBKSA-N |
| PubChem CID | 58423153 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |