China (Mainland)
1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale 1361951-15-6 CAS NO.1361951-15-6
- FOB Price: USD: /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: T/T,Other
- Available Specifications:
99%(1-5)Gram98%(1-5)Gram
- Product Details
Keywords
- TP-3654
- TP-3654; TP3654; TP 3654
- 1361951-15-6
Quick Details
- ProName: 1361951-15-6 good supplier fast delive...
- CasNo: 1361951-15-6
- Molecular Formula: C22H25F3N4O
- Appearance: Powder
- Application: Scientific research
- DeliveryTime: Prompt
- PackAge: As required
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: keep sealed and keep from direct light
- Transportation: By Sea/Air/FedEx
- LimitNum: 1 Gram
- Moisture Content: N/A
- Impurity: N/A
- Grade: Industrial Grade，Pharma Grade
Superiority
1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively). It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
Alternate Name2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-olAppearanceWhite to off-white solidCAS #1361951-15-6Molecular FormulaC??H2??F?N?OMolecular Weight418.46Purity≥98% by HPLCSolubilityDMSOSMILESCC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)OInChiInChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)InChi KeyXRNVABDYQLHODA-UHFFFAOYSA-NPubChem CID66598080HandlingProtect from air and lightStorage Conditions-20°CShipping ConditionsGel PackUSAGEFor Research Use Only! Not For Use in Humans.
Details
| Alternate Name | 2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 1361951-15-6 |
| Molecular Formula | C??H2??F?N?O |
| Molecular Weight | 418.46 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O |
| InChi | InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28) |
| InChi Key | XRNVABDYQLHODA-UHFFFAOYSA-N |
| PubChem CID | 66598080 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |